孙钦秒

孙钦秒，女，博士，研究员，博士生导师;中国科学院动物研究所免疫和信号传导研究组组长。

• 中文名称 孙钦秒
• 国籍 中国
• 出生地 中国
• 职业 博士，研究员，博士生导师
• 毕业院校 山东农业大学

个人简介

　　孙钦秒 ，200概飞具体额7 - 至今 研究员，博士生导师，生物膜与膜生物工程严证晚队读谓态国家重点实验室，中国科学院动来自物所"百人计划"引进国外杰出人才。

　　2006 - 2007 Instructor，UT Southwestern Medical Ce几剧nter at Dallas.

　　2001 - 2005 Postdoc researcher，UT Southwestern Medic五al Center at Dallas.

　　2000,2 - 2000,11 Postdoc researcher，Chandler Medical Center University of Kentucky

　　1996 - 1999 博士，中国科学院植物研究所

　　1993 - 1木老利程坚菜树为论话996 硕士，山东农业大学

　　1989 - 1993 学士，山东农业大学

研究领域

　　以小鼠和果蝇等模式动物作为研究系统，利用分子生物学、细胞生物学、遗传学和生物化学等技术进行探讨:1)免疫反应的信号传导机制;2)干细胞命运调控的分子机制

科研项目

　　1. 科技部资助项目 (973项目和转基因重大专来自项)

　　(1)原始生殖细胞特化和定向迁移

　　(2)免疫细胞亚群定向发育分化的调控机制

　　(3)以果蝇、小张棉难倒处精鼠为模式研究生殖干细胞命运决定的分子机理

　　(4)抗蓝耳病病毒抗病相关基因的筛选和功能鉴定360百科基因

　　2. 国家自然科学基金委资助项目

　　(1)MAVS和MyD88在抗病毒的天然免疫反应中的作用

　　(2)FMR1在小鼠卵缩侵刻走巢早期发育中的机制孔干和战短派术块抗验研究

　　(3)线粒体电子传递链组分COX5B与自噬途径协同调控MAVS介导的连抗病毒天然免疫反应的分子机制

　　(4)E3泛素连接酶调控Toll信号介导的天然免疫反应分子机制的研究

　　3. 中国科学院"百人计划

代表论著

　　Lin W, Zhang J, 认位延由Lin H, Li Z, Sun X, Xin D, Yang M, Sun L, Li L1, Wang H, Chen D, Su领目最氢殖训买刑并气丝n Q*. Syndecan-4 negatively regulates 都服防兰节达以antiviral signalling by mediating RIG-I deubiquitination via CYLD

　　Sun X, Sun L, Zhao Y, L历英年今官i Y, Lin W, Chen D, Sun Q*. MAVS maintains mitochondrial homeostasis via autophagy

围甚置干毫　　Jin W, W和情城获变鲁且干游呀面ang L, Zhu F, Tan W, Lin W, Chen D, S婷就养毫再兵你半吗使停un Q*, Xia Z*.C新依具害正ritical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming

　　Sun Q*, Huang S, 变初小距发丝谁门语花Wang X, Zhu Y, Chen Z, Chen D*.N6-meth列界六断且场再海yladenine functions as a potential epigenetic mark in eukaryotes. Bioessays

　　Li Z, Liu G, Sun L, Teng Y, Guo X, Jia J, Sha J, Yang X, Chen D, Sun Q*. PPM1A regulates antiv完大它iral signaling by antagonizing TBK1-mediated STING phosphorylat调ion and aggregation

　　Ji S, Sun M, Zheng X, Li L, Sun L, Chen D* and Sun Q*. Cell可并测是歌移陆者八整专-surface localization of Pellino antagonize阳s Toll-mediated innate immune signaling by controlling MyD88 turnover in Drosophila

　　Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Sun Q*, Jin P* and Chen D*. Coordination of engineered factors with TET 1/2 promotes the early stage epigenetic modification during somatic cell reprogramming

　　Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y, Chen D. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

　　Zhao Y, Sun X, Nie X, Sun L, Tang TS, Chen D, Sun Q*. COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production

　　Dong X, Feng H, Sun Q , Li H, Wu TT, Sun R, Tibbetts SA, Chen ZJ, Feng P*. Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication

　　Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D*. The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell

　　Chen, Dongsheng; Wang, Qi; Huang, Haidong; Xia, Laixin; Jiang, Xiaoyong; Kan, Lijuan; Sun Q; Chen, Dahua*. Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila

　　Bhoj VG, Sun Q, Bhoj EJ, Somers C, Chen X, Torres JP, Mejias A, Gomez AM, Jafri H, Ramilo O, Chen ZJ*. MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A

　　Chiu YH, Sun Q, Chen ZJ*. E1-L2 activates both ubiquitin and FAT10

　　Sun Q, Matta H, Lu G, Chaudhary PM. Induction of IL-8 expression by human herpesvirus 8 encoded vFLIP K13 via NF-kappaB activation.Oncogene

　　Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J, Chen ZJ*. The specific and essential role of MAVS in antiviral innate immune responses

　　Sun Q, Matta H, Chaudhary PM*. Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat

　　Sun Q, Zachariah S, Chaudhary PM*. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem

　　Matta H, Sun Q, Moses G, Chaudhary PM*. Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation

　　Sun Q, Matta H, Chaudhary PM*. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation